Inner Ear Disorders ‘Linked To Hyperactivity ‘


Inner-ear problems could be a cause of hyperactive behaviour, research suggests.

A study on mice, published in Science, said such problems caused changes in the brain that led to hyperactivity.

It could lead to the development of new targets for behaviour disorder treatments, the US team says.

A UK expert said the study’s findings were “intriguing” and should be investigated further.
Behavioural problems such as ADHD are usually thought to originate in the brain.

But scientists have observed that children and teenagers with inner-ear disorders – especially those that affect hearing and balance – often have behavioural problems.

However, no causal link has been found.
The researchers in this study suggest inner-ear disorders lead to problems in the brain which then also affect behaviour.

Gene mutation
The team from the Albert Einstein College of Medicine of Yeshiva University in New York noticed some mice in the lab were particularly active – constantly chasing their tails.

They were found to be profoundly deaf and have disorders of the inner ear – of both the cochlea, which is responsible for hearing, and the vestibular system, which is responsible for balance.

The researchers found a mutation in the Slc12a2 gene, also found in humans.
Blocking the gene’s activity in the inner ears of healthy mice caused them to become increasingly active.

The researchers then examined the striatum, an area in the centre of the brain area that controls movement.
They found higher-than-normal levels of two proteins, pERK and pCREB.

Mice with the gene flaw were given injections of haloperidol, a medicine already used to treat tics – uncontrollable movement – in humans.
It was seen to counteract the high protein levels, and mouse activity patterns returned to normal.

The researchers suggest the same process could be targeted in people, and that medications could be developed to help manage hyperactivity in children with inner-ear disorders.

Prof Jean Hebert, the lead scientist, said: “Our study provides the first evidence that a sensory impairment, such as inner-ear dysfunction, can induce specific molecular changes in the brain that cause maladaptive [counterproductive] behaviours traditionally considered to originate exclusively in the brain.”

Anita Thapar, professor of child and adolescent psychiatry at Cardiff University’s Institute of Psychological Medicine and Clinical Neurosciences, said it was an “intriguing study and set of findings”.

Prof Thapar, whose research has suggested there could be a genetic link to attention deficit hyperactivity disorder (ADHD), added: “It certainly raises the issue that we ought to critically consider what contributes to the links between sensory impairments and specific behaviours/disorders.”

But she added there should be caution about directly extrapolating the findings to humans.
“ADHD, like most neuropsychiatric and medical disorders, is not caused by a single mutation.
“On the other hand animal models allow for experimental manipulation in a way that cannot be achieved in humans and the results can help shape hypotheses to test in humans.”

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