By Dr. Raphael Nyarkotey Obu, RND, PhD.
You can never get a cup of tea large enough or a book long enough to suit me. One of the teas that crosses my mind reading that is the powerfully beneficial hibiscus tea.
In my research, I have identified seven controlled human clinical trials evaluating hibiscus preparations. Five of the trials evaluated impact on blood pressure, three trials evaluated impact on serum lipid profiles, and one trial evaluated impact on plasma glucose level. This is very interesting. Medicine has evolved and it is time to integrate evidence based natural remedies into conventional stream.
Approximately 15%-30% of the plant is made up of plant acids, including citric, malic, tartaric acids and allo-hydroxycitric acid lactone—i.e. hibiscus acid which is specific to this plant. Other chemical constituents are many, including alkaloids, L-ascorbic acid, anthocyanin, Beta-carotene, Beta-sitosterol, citric acid, polysaccharides arabins and arabinogalactans, quercetin, gossypetin and small amounts of galactose, arabinose, glucose, xylose, mannose and rhamnose. The calyces of H. sabdariffa are prolific in many modern commercial blends of cold and hot drinks due to its pleasing taste, as well as having decorative, culinary and medicinal uses.
In Egypt and the Sudan, it is used as a beverage that helps to lower the body temperature, to treat cardiac conditions, and as a diuretic. In African folk medicine it has been used for its spasmolytic, antibacterial, cholagogic, diuretic and anthelmintic properties. Other uses in North Africa include cough and sore throat, while the leaf pulp is made into a topical application for external wounds and abscesses. In Europe, the dried calyces (the cup-like structures that are formed by the sepals) are used mostly as a tea. Hibiscus is commonly used in combination with lemon balm and St John’s wort for restlessness and poor sleep onset.
Historically, folk medicine has used H. sabdariffa for the treatment of high blood pressure, liver diseases and fevers. In large amounts, hibiscus tea acts as a mild laxative. In Iran, it is a traditional treatment for high blood pressure which is the focus of several studies, as is cholesterol reduction. Hibiscus has been used historically for high blood pressure and contains several important ingredients including alkaloids, anthocyanins and quercetin. It is thought that the antioxidant and diuretic effects of hibiscus are its most important mechanisms in lowering blood pressure.
Summary of Research on Cardiovascular Applications
Scientific interest in Hibiscus has grown in the last several years with a small burst of published research studies, especially in the area of dyslipidemia and hypertension. Over twenty years ago, water extracts of hibiscus flowers were reported to have a relaxation effect on the uterus and to lower the blood pressure.
Studies in both animal and human models have demonstrated that extracts or infusions affect atherosclerosis mechanisms, blood sugar, lipids and blood pressure .In 2007, a clinical trial showed that Hibiscus reduced cholesterol by 8.3% to 14.4% after just one month. A total of 42 subjects were randomized to 3 groups for the study, conducted in Taiwan. The hibiscus extract capsules contained 500 mg of dried herb by macerating 150 g of hibiscus flowers in 6 L of hot water for 2 hours and then drying and filtering the extract. Group 1 received 1 capsule of extract 3 times daily (1,500 mg/day), group 2 received 2 capsules 3 times daily (3,000 mg/day), and group 3 received 3 capsules 3 times daily (4,500 mg/day) Overall, subjects in group 2 responded best to the hibiscus extract treatment.
Groups 1 and 2, but not group 3, experienced a significant reduction in serum cholesterol levels at week 4, compared with baseline levels. In addition, group 2 experienced a significant reduction in serum cholesterol levels at week 2, compared with baseline levels. At week 2, there was a 42.9% responder rate in groups 1 and 3 and a 64.3% responder rate in group 2. By week 4, group 2 had a cholesterol reduction response from 71.4% of the subjects. In group 1, 50.0% were responders, and 42.9% subjects in group 3 were responders at week 4. It appeared that group 2, taking 1,000 mg three times daily, was the optimum dose in achieving cholesterol reduction effects. While this study is small with a small number of subjects in each of the study groups, as well as a short duration of 4 weeks, there was indeed a clear effect with significant reductions in serum cholesterol seen as early as week 2, in the 1,000 mg tid group. Oddly enough, the responders in group 3, receiving the highest dose (4,500 mg/day), had the smallest response to the hibiscus extract with an average of 8.3% reduction at week 4. Group 1 received a 14.4% reduction at week 4.
In 2009, 60 Type 2 diabetics, mostly women, were given either Hibiscus tea from Saudi Arabia or black tea, 1 cup twice per day. Seven individuals withdrew from the study and after one month, mean HDL cholesterol increased significantly (48.2 mg/dL to 56.1 mg/dL) whereas apolipoprotein A1 and lipoprotein (a) were not significant. There was also a significant decrease in the mean of total cholesterol (236.2 to 218.6), LDL cholesterol (137.5 to 128.5), triglycerides (246.1 to 209.2) and Apo-B100 (80.0 to 77.3) in the Hibiscus group. Only HDLc showed a significant change in the black tea group (46.2 to 52.01). Something as simple as Hibiscus tea in a diabetic, is a welcomed intervention. Achieving a 7.6% decrease in total cholesterol, an 8.0% decrease in LDLc, a 14.9% decrease in triglycerides, a 3.4% decrease in Apo-B100, a 4.2% increase in Apo-A1 and a 16.7% increase in HDLc is no small accomplishment with merely two cups of tea per day.
Hibiscus extract was also studied in 222 patients, some with and some without metabolic syndrome (MS). A total daily dose of 100 mg Hibiscus sabdariffa extract powder (HSEP) was given for one month to men and women, 150 without MS and 72 with MS. They were randomly assigned to a preventive diet, HSEP treatment or diet combined with HSEP treatment. The MS patients receiving HSEP had significantly reduced glucose, total cholesterol and LDL-c and increased HDL-c. A triglyceride lowering effect was seen in all groups but was only significant in the control group that was treated with diet. The triglyceride/HDL-c ratio was also significantly reduced with HSEP in the control and MS groups, indicating an improvement in insulin resistance. It has been hypothesized that the anthocyanins regulate adipocyte function, which has definite and important implications for both preventing and treating metabolic syndrome. Due to both its hypolipidemic and hypotensive effects, Hibiscus extract would be an excellent option for individuals with metabolic syndrome.
A double-blind, placebo control, randomized trial in 69 subjects with elevated LDL and no history of coronary heart disease did not appear to show a blood lipid lowering effect from Hibiscus extract. The treatment group received 1,000mg/day Hibiscus extract for 90 days in addition to dietary and physical activity. Body weight, serum LDL cholesterol and triglyceride levels decreased in both the extract and placebo groups, with no significant differences between the two. It is likely that the positive effects were due to dietary and exercise activity. One wonders why the results of this study were negative and the three previous studies above, showed positive results. The doses and product used in all four studies were different. One a tea, another used dried powdered flowers, another used a standardized extract powder of the sepals of the flowers, and this one, an ethyl alcohol/water extract, dried and then powder of the leaves. It is reasonable to consider that these different preparations would yield different results. With more consistent product selection and dosages used in larger randomized trials, we would hope that this would clarify the best intervention to use.
Hypertension is another area indicated for the use of Hibiscus. The blood pressure lowering effects of sour tea (ST) Hibiscus sabdariffa was compared with black tea (BT) in type II diabetics with mild high blood pressure. Patients were randomly assigned to drink one cup of Hibiscus or black tea two times per day for one month. The average systolic blood pressure (SBP) in the Hibiscus group decreased from 134.4 + 11.8 mm Hg at the start of the study to 112.7 + 5.7 mm Hg after 1 month. The average SBP changed from 118.6 + 14.9 to 127.3 + 8.7 mm Hg in the black tea group during the same time period. There were no statistically significant effects on the mean diastolic blood pressure in either group. This drop in systolic blood pressure is clinically relevant, decreasing systolic blood pressure in pre-hypertensive ranges, to normal systolic blood pressure. We do not know if systolic blood pressure would be lowered by one cup of Hibiscus tea in those with stage I or stage II hypertension.
A randomized, controlled, double-blind clinical comparison study was done of Hibiscus sabdariffa extract with lisinopril on patients with stage I or II hypertension. A dried powdered Hibiscus extract was delivered in 250 mg of water containing a total of 250 mg anthocyanins from Hibiscus extract for 4 weeks and the lisinopril group received 10 mg/day. Results showed that the Hibiscus extract decreased blood pressure from 146/98 mm/Hg to 130/86 mm/Hg. Blood pressure reductions were lower than with lisinopril, but the Hibiscus extract did not modify plasma potassium levels and did not have the mineralocorticoid effects. Based on the study data, the authors concluded that the Hibiscus extract did have a significant antihypertensive action, and through at least two mechanisms of action: diuretic effects likely as an aldosterone antagonist and ACE inhibitory effects. It was also reassuring to note in the study that the diuretic activity did not alter plasma potassium levels and did not have mineralocorticoid effects.
A Cochrane review of Hibiscus effects on blood pressure published in 2010 resulted in five articles. The reviewers included randomized controlled trials (RCTs) of 3-12 weeks in duration that compared Hibiscus to either placebo or no intervention at all. All five of these studies found significant reductions in systolic blood pressure. While they could not draw reliable conclusions about the benefit of Hibiscus for controlling or lowering blood pressure in hypertensive patients, in the articles that met their inclusion criteria, they did state that beneficial effects were found in the treatment of hypertension with Hibiscus, but that well-designed, placebo-controlled RCTs were needed. The safety profile of Hibiscus is excellent with no proven adverse reactions. Hibiscus also has a Generally Recognized as Safe (GRAS) status.
Why choose Nyarkotey Tea for Cardiovascular Health
Look for tea made from real Hibiscus sabdariffa and concentrated such as Nyarkotey Tea. It is highly formulated using bioscalar Technology. Nyarkotey Tea is a clinical grade, advanced, comprehensive phytomedicine product approved by the FDA for Cardiovascular Health and general wellbeing. Nyarkotey Tea is also designed to help guard against Cardiovascular Health and general wellbeing. The Nyarkotey Tea made with concentrated bioenergized Hibiscus Sabdariffa is termed as ‘Heart insurance Tea”
Lab study conducted at the Kwame Nkrumah University of Science and Technology on efficacy showed the product Dr. Nyarkotey Herbal Tea produced dose-dependent reduction in the arterial blood pressure of the anaesthetized cat comparable to acetylcholine. The depressor effects of acetylcholine and Dr. Nyarkotey Herbal tea on the blood pressure of the anaesthetized cat were inhibited by 72.3+5.21% and 55.6 + 6.82% respectively, suggestive of muscarinic mediation.
The remarks states that, as per the findings, Dr. Nyarkotey Herbal Tea has hypotension effect and hence could be used in the management of hypertension. The No-Observable-Adverse-Effect level (OAEL) is greater than five times the stated daily dosage (7.0ml/kg) indicated by the manufacturer. In conclusion Hibiscus Tea has been proven scientifically to support cardiovascular Health.
Dr. Raphael Nyarkotey Obu, RND, PhD is an established Natural Medicine Researcher and formulator of the breakthrough Men’s Formula for Prostate Health, Nyarkotey Tea for Cardiovascular Health and Women’s Formula for general women’s Health. Enquires, 0541234556 or Nyarkotey College of Holistic Medicine, Tema community 7, Post office.